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. 2020 Sep 4;319(4):H893–H905. doi: 10.1152/ajpheart.00379.2020

Fig. 5.

Fig. 5.

Ventricular ectopy, aging, heart rate variability (HRV), and survival. A: ECGs traces and RR interval duration for a C57Bl/6 mouse at 12 mo of age document the appearance of an isolated premature ventricular complex (PVC; gray arrow). B: ECGs traces and RR interval duration for a S571E mouse at 3 mo of age document the appearance of recurrent PVCs (gray arrows). C: quantitative data for aging C57Bl/6 and S571E mice without (w/o) or presenting isolated or multiple PVCs (PVCpos). m, months. *P < 0.05 vs. ~4 mo using χ2-test for trend. D: quantitative data for HRV parameters in C57Bl/6 and S571E mice without (n = 113, 88) and with PVC(s) (PVCpos, n = 15, 9). SDRR, standard deviation of RR intervals; LF/HF, low frequency-to-high frequency ratio. *P < 0.05 vs. w/o. E: survival curves for male C57Bl/6 (n = 79) and S571E (n = 185) mice and for female C57Bl/6 (n = 40) and S571E (n = 158) mice. For the 2 sexes, survival curves for the 2 genotypes were not significantly different using Gehan–Breslow–Wilcoxon and log-rank (Mantel–Cox) tests.