Table 3:

Hazard ratios of 1-year all-cause mortality associated with individual comorbidities among patients hospitalized with acute decompensated heart failure, stratified by heart failure type. The community surveillance component of the Atherosclerosis Risk in Communities study, 2005–2014^*.

Comorbidity	HFpEF	HFrEF	Interaction by HF type
	HR (95% CI)	HR (95% CI)	P-value
Coronary artery disease	1.13 (0.96 – 1.34)	0.97 (0.84 – 1.12)	0.1
Myocardial infarction	1.05 (0.86 – 1.29)	1.02 (0.88 – 1.19)	0.7
Peripheral artery disease	1.33 (1.06 – 1.68)	1.43 (1.19 – 1.72)	0.7
Hypertension	0.85 (0.66 – 1.04)	1.11 (0.89 – 1.38)	0.08
Atrial fibrillation	1.34 (1.14 – 1.57)	0.97 (0.83 – 1.13)	0.003
Stroke / TIA	1.40 (1.16 – 1.69)	1.13 (0.95 – 1.34)	0.1
Valvular heart disease	1.27 (1.06 – 1.53)	1.19 (1.01 – 1.40)	0.6
Pulmonary hypertension	1.42 (1.17 – 1.72)	1.26 (1.03 – 1.54)	0.5
Obesity (BMI ≥30)	0.88 (0.73 – 1.06)	0.90 (0.76 – 1.07)	1.0
Obesity categories			0.2
BMI <30	ref.	ref.
BMI 30–35	0.76 (0.60 – 0.98)	0.94 (0.77 – 1.16)
BMI (BMI ≥35)	1.00 (0.80 – 1.24)	0.85 (0.66 – 1.09)
Diabetes mellitus	1.09 (0.92 – 1.29)	1.07 (0.93 – 1.23)	0.9
Chronic kidney disease	1.58 (1.29 – 1.95)	1.69 (1.41 – 2.02)	0.6
Chronic bronchitis / COPD	1.42 (1.20 – 1.68)	1.28 (1.09 – 1.49)	0.3
Sleep apnea	1.19 (0.95 – 1.50)	0.89 (0.68 – 1.16)	0.03
Depression	1.51 (1.25 – 1.84)	1.38 (1.14 – 1.68)	0.6
Anemia	1.70 (1.43 – 2.01)	1.60 (1.40 – 1.84)	0.8
Thyroid disease	1.37 (1.14 – 1.66)	1.12 (0.93 – 1.36)	0.2

^*Footnote: models adjusted for age, race, sex, year of admission, and hospital of admission. Definition of coronary artery disease include myocardial infarction. Chronic kidney disease not abstracted in 2014.

Abbreviations: HFpEF = heart failure with preserved ejection fraction, HFrEF = heart failure with reduced ejection, HF = heart failure