Table 1. Functional analysis of the oral dysbiosis dataset using molecular function GO terms.

Tool	EggNOG mapper	MEGAN	MetaGOmics	MPA	ProPHAnE	Unipept
Type of functional annotation	eggNOG orthologous groups	eggNOG orthologous groups	GO terms	Proteins	Protein families, eggNOG orthologous groups	GO terms
Total number of annotation groups	18,440	1,665	2,829	23,169	3,999	3,471
Total (and unique) number of translated GO terms for all ontologies	533,066 (6,155)	76,529 (4,155)	2,829 (2,829)	77,204 (1,056)	189,054 (2,598)	3,471 (3,471)
Total (and unique) number of translated molecular function GO terms	88,582 (1,411)	21,212 (1,613)	900 (900)	42,084 (634)	57,208 (1,057)	1,726 (1,726)
Total number of molecular function GO terms exclusive to the tool	265	168	113	1	16	394
Total number of molecular function expanded GO terms	1,466	1,693	1,002	974	1,135	2,249
Total number of molecular function expanded GO terms exclusive to the tool	204	118	80	1	11	447