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[Preprint]. 2020 Nov 5:2020.11.04.361154. [Version 1] doi: 10.1101/2020.11.04.361154

Figure 2. Inhibition of live SARS-CoV-2 entry by [SARS-CoV-2-HRC-peg4]2-chol peptide.

Figure 2.

The percentage inhibition of infection is shown on VeroE6 and VeroE6-TMPRSS2 cells with increasing concentrations of [SARS-CoV-2-HRC-peg4]2-chol. A DMSO-diluted stock (A, as used in ferrets) and sucrose-diluted stock (B, potential formulation for human use) were tested side-by-side. Inhibitory concentrations 50% and 90% were calculated (dotted lines). (C) Inhibitory concentrations 50% and 90% of [SARSHRC-PEG4]2-chol in live SARS-CoV-2 viral infection assays in VeroE6 cells with or without TMPRSS2 protease overexpression.