Table 3:
Mendelian randomization estimates for causal effects of circulating AMH on breast cancer and PCOS risk.
| Outcome | Method | Odds Ratio | 95% CI | p |
|---|---|---|---|---|
| Breast Cancer | IVW | 1.00 | 0.74 – 1.36 | 0.98 |
| Wald ratio estimate for rs10417628 (AMH) | 0.99 | 0.87 – 1.12 | 0.85 | |
| Wald ratio estimate for rs13009019 (TEX41) | 0.84 | 0.72 – 0.97 | 0.02 | |
| Wald ratio estimate for rs16991615 (MCM8) | 1.60 | 1.37 – 1.87 | 1.79 × 10−9 | |
| Wald ratio estimate for rs11683493 (CDCA7) | 0.76 | 0.65 – 0.89 | 9.41 × 10−4 | |
| PCOS | IVW | 1.29 | 0.85 – 1.95 | 0.23 |
| Wald ratio estimate for rs10417628 (AMH) | 1.27 | 0.64 – 2.56 | 0.49 | |
| Wald ratio estimate for rs13009019 (TEX41) | 1.66 | 0.80 – 3.45 | 0.18 | |
| Wald ratio estimate for rs16991615 (MCM8) | 1.75 | 0.83 – 3.69 | 0.14 | |
| Wald ratio estimate for rs11683493 (CDCA7) | 0.66 | 0.29 – 1.50 | 0.32 |
Odds ratio and 95%CI are per 1 unit increase in inverse normally transformed AMH.
AMH, anti-Müllerian hormone; PCOS, polycystic ovary syndrome; IVW, inverse variance weighted; MR, Mendelian randomization.