Table 1.
Characteristics of Global Lipids Genetics Consortium and UK Biobank datasets
| Exposures | Consortium | No. SNPs | Sample size | Population |
|---|---|---|---|---|
| HDL-cholesterol | GLGC | 71 | 92 860 | 90% European |
| LDL-cholesterol | 57 | 83 198 | ||
| Total cholesterol | 73 | 92 260 | ||
| Triglycerides | 40 | 91 598 | ||
|
| ||||
| Main outcomes | Dataset | No. cases/sample size | Population | |
|
| ||||
| Aortic stenosis | UK Biobank | 1961/432 173 | 100% European | |
| Aortic regurgitation | 736/432 173 | |||
| Mitral regurgitation | 2213/432 173 | |||
| Outcomes for sensitivity analysis | ||||
| Myocardial infarction | 15 391/432 173 | |||
| Heart failure | 5161/432 173 | |||
| Aortic valve replacement | 1233/432 173 | |||
| Demographic variables | ||||
| Age (years), mean (SD) | 56.8 (8.0) | |||
| Male gender, n (%) | 198 623 (45.9) | |||
GLGC, Global Lipids Genetics Consortium; HDL, high density lipoprotein; LDL, low density lipoprotein; SD, standard deviation; SNP, single nucleotide polymorphism.