Table 3.

Two-sample Mendelian randomization estimations showing the effect of plasma lipids on aortic regurgitation

Methods	Exposure	Odds ratioa	95% CI		P-value	Ph	Q-statistics
Inverse-variance weighted	HDL-cholesterol	0.87	0.66	1.15	0.35	0.40	72.1
MR-Egger		0.82	0.53	1.25	0.35
Weighted median		0.73	0.47	1.13	0.15
MR-PRESSOb		NA	NA	NA	NA
MR-Egger interceptc		0.005	−0.017	0.027	0.65
Inverse-variance weighted	LDL-cholesterol	0.97	0.73	1.30	0.88	0.09	70.2
MR-Egger		0.94	0.59	1.51	0.80
Weighted median		1.10	0.73	1.66	0.63
MR-PRESSOb		NA	NA	NA	NA
MR-Egger interceptc		0.003	−0.027	0.33	0.83
Inverse-variance weighted	Total cholesterol	0.87	0.67	1.13	0.32	0.51	70.9
MR-Egger		1.06	0.67	1.69	0.80
Weighted median		1.11	0.74	1.69	0.61
MR-PRESSOb		NA	NA	NA	NA
MR-Egger interceptc		−0.013	−0.038	0.013	0.33
Inverse-variance weighted	Triglycerides	1.01	0.70	1.45	0.94	0.19	46.4
MR-Egger		1.21	0.70	2.09	0.50
Weighted median		1.26	0.77	2.06	0.36
MR-PRESSOb		NA	NA	NA	NA
MR-Egger interceptc		−0.013	−0.044	0.018	0.39

The best causal estimation highlighted in bold.

CI, confidence interval; HDL, high density lipoprotein; LDL, low density lipoprotein; NA, not applicable; P_h, P-value for heterogeneity.

^aOdds ratio per 1 SD increase.

^bNo significant outliers.

^cRegression coefficient (95% CI).