Table 4.

Two-sample Mendelian randomization estimations showing the effect of plasma lipids on mitral regurgitation

Methods	Exposure	Odds ratioa	95% CI		P-value	Ph	Q-statistics
Inverse-variance weighted	HDL-cholesterol	0.84	0.70	1.02	0.08	0.0009	100.4
MR-Egger		0.96	0.72	1.29	0.80
Weighted median		0.97	0.76	1.23	0.79
MR-PRESSOb		NA	NA	NA	NA
MR-Egger interceptc		−0.009	−0.024	0.006	0.25
Inverse-variance weighted	LDL-cholesterol	1.10	0.93	1.30	0.23	0.12	68.5
MR-Egger		1.07	0.81	1.40	0.65
Weighted median		1.08	0.85	1.37	0.52
MR-PRESSOb		NA	NA	NA	NA
MR-Egger interceptc		0.003	−0.014	0.020	0.73
Inverse-variance weighted	Total cholesterol	1.12	0.95	1.32	0.14	0.14	84.7
MR-Egger		1.19	0.88	1.60	0.24
Weighted median		1.08	0.85	1.39	0.50
MR-PRESSOb		NA	NA	NA	NA
MR-Egger interceptc		−0.004	−0.020	0.012	0.65
Inverse-variance weighted	Triglycerides	1.31	1.04	1.65	0.02	0.05	54.0
MR-Egger		1.30	0.92	1.85	0.13
Weighted median		1.29	0.96	1.73	0.09
MR-PRESSOb		NA	NA	NA	NA
MR-Egger interceptc		0.000	−0.019	0.020	0.97

The best causal estimation highlighted in bold.

CI, confidence interval; HDL, high density lipoprotein; LDL, low density lipoprotein; NA, not applicable; P_h, P-value for heterogeneity.

^aOdds ratio per 1 SD increase.

^bNo significant outliers.

^cRegression coefficient (95% CI).