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. 2020 Jun 24;161(12):2841–2851. doi: 10.1097/j.pain.0000000000001975

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Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Trajectories—red colour (-1-) indicates the first trajectory group, green (-2-) the second, blue (-3-) the third, black (-4-) the fourth, yellow (-5-) the fifth, and orange (-6-) the sixth group; (A) pain trajectories in the VIDEO trial; (B) functional limitation trajectories in the VIDEO trial; (C) pain trajectories in the OAI study with a window of 3-year follow-up comparable to the VIDEO trial duration; people with minimal-to-neglected knee pain—trajectory 1; low-fluctuating phenotype—trajectory 2 corresponding to the trajectory one in the VIDEO trial; mild-increasing phenotype—trajectory 3 corresponding to the trajectory 2 in the VIDEO trial; moderate-treatment-sensitive phenotype—trajectories 4 and 5 corresponding to the trajectory 3 in the VIDEO trial; high-treatment-insensitive phenotype corresponding to the trajectory 4 in the VIDEO trial; (D) functional limitation trajectories in the OAI study with a window of 3-year follow-up equivalent to the VIDEO trial duration. OAI = Osteoarthritis Initiative.