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. Author manuscript; available in PMC: 2020 Nov 10.
Published in final edited form as: ACS Chem Neurosci. 2019 Aug 23;10(9):4102–4111. doi: 10.1021/acschemneuro.9b00329

Figure 4.

Figure 4.

Compounds decreased ROS and NO produced by microglia. BV2 cells were stimulated with 500 ng/mL LPS after pre-treatment with derivatives at μM concentrations for 1 h. After this time, the levels of (a) ROS and (b) NO were measured. Values are mean± SEM of three replicates performed by triplicate and expressed as percentage of LPS control cells. Statistical significance was determined with one way ANOVA test followed by Dunnett’s post-hoc test. LPS control cells are compared to inactivated microglia (##p<0.01, ###p<0.001). Treatments with compounds are compared to cells treated only with LPS (*p<0.05, **p<0.01, ***p<0.001).