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Common interactions of dual inhibitors in MAP4K5 and TAOK1. (A) Hydrogen-bond and hydrophobic interactions for each compound in MAP4K5 and TAOK1 are listed in green. Common interactions between the target kinases is highlighted in red box. (B) The docking pose of compound 1 in MAP4K5 (blue) and TAOK1 (purple) is overlaid. Common interacting residues in target kinase binding site is listed as shown and represented as sticks.
