(
A) Micro-C XL in mitotically arrested cells detects more positioned loops than Hi-C. Comparison of contact maps from mitotically arrested cells produced with Micro-C XL (top), Hi-C (center) (
Schalbetter et al., 2019), and Hi-C (bottom) (
Paldi et al., 2020). Contact maps show contacts between chromosomes VII to X at 6.4 kb resolution (first column). Contact maps show successive zoom-ins of chromosome VII (from the full 1090 kb to a 90 kb region), across multiple resolutions (from 1.6 kb to 100 bp). Standard colormap scheme that uses the shades of red from white (no detectable interactions) to black (maximum interactions detected) in log10 scale. (
B) Micro-C detects positioned loops in mitotically arrested, but not in asynchronous cells. Comparison of contact maps from mitotically arrested cells with Micro-C XL (top), and unsynchronized cell with Micro-C XL (bottom) (
Hsieh et al., 2016), Contact maps show contacts between the whole genome (first column), followed by contacts from chromosomes XII to XV at 6.4 kb resolution (second column). The following contact maps show successive zoom-ins of chromosome XII (from the full 924 kb to a 60 kb region), across multiple resolutions (from 1.6 kb to 100 bp). Standard colormap scheme uses the shades of red from white (no detectable interactions) to black (maximum interactions detected) in log10 scale.