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. 2020 Oct 27;11:548604. doi: 10.3389/fimmu.2020.548604

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Copyright © 2020 Koudriavtseva, Stefanile, Fiorelli, Lapucci, Lorenzano, Zannino, Conti, D’Agosto, Pimpinelli, Di Domenico, Mandoj, Giannarelli, Donzelli, Blandino, Salvetti and Inglese

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DSC perfusion maps and their overlap with structural masks in an MS patient. (A). AIF curve created by using global, automatic, and outside-artery technique (B). Leakage map, obtained through the leakage correction function, to minimize leakage effect both on Gadolinium and no Gadolinium enhancing lesions (C). a. CBV map; b. CBF map; c. MTT map. (D). a. NAWM (red), obtained by subtracting from white matter (WM binary) masks the different types of lesions, linearly registered to CBV map; b. thalamus (yellow), caudate (green), putamen (light blue), globus pallidus (blue), obtained by using FIRST software, linearly registered to CBV map. AIF, arterial input function; CBV, cerebral blood volume; CBF, cerebral blood flow; MTT, mean transit time; NAWM, normal appearing white matter.