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. 2020 Oct 29;12(20):20235–20253. doi: 10.18632/aging.103772

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Copyright: © 2020 Du et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Knockdown of ARHGEF11 attenuates EMT, cell cycle progression and induces cell apoptosis via β-catenin-dependent way. (A) Micrographs of indicated cell clones. (B) The mRNA expression of a series of EMT markers and inducers in indicated cells. (C) Relative expression of E-cadherin, N-cadherin, Vimentin and ZEB1 detected by western blot in the indicated cells. (D) Immunofluorescence assay of E-cadherin, Vimentin, and ZEB1 expression in the indicated cells. The merged images show overlays of ZEB1 (red) and nuclear staining by DAPI (blue); scalebar: 20 mm. (E) The mRNA levels of CDK1, CDK2, cyclinD1 and cyclinE in indicated cells (F) Relative expression of cyclinD1 and Cleaved Caspase-3 detected by western blot in the indicated cells.