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Graphical model displaying the mechanisms of ARHGEF11 in regulating cell cycle and EMT via activating β-catenin. Upregulation of ARHGEF11 promotes β-catenin nuclear translocation from cell membrane. β-catenin activates cyclinD1 transcription, which then leads to cell cycle progression. At the same time, β-catenin enhances ZEB1 transcription, which can inhibit E-cadherin expression, thereby inducing EMT.
