Table 2. Univariate and multivariate analysis of risk factors associated with OS.

Variable	Univariate analysis of risk factors associated with OS			Multivariate analysis of risk factors associated with OS
	P	HR	95% CI	P	HR	95% CI
Age	0.375	0.993	0.979-1.008	NA
Gender (M v F)	0.120	0.658	0.389-1.114	0.135
ARHGEF11	<0.001	2.465	1.660-3.661	<0.001	2.861	1.878-4.359
HBV (P v N)	0.387	1.270	0.739-2.180	NA
Cirrhosis (Y v N)	0.249	1.247	0.858-1.813	0.082
Tumor number (S v M)	0.001	1.917	1.284-2.861	0.222
AFP	0.001	1.349	0.943-1.930	0.136
Tumor size	0.002	1.075	1.027-1.124	0.032	1.050	1.004-1.097
AJCC-TNM stage	<0.001			0.056
I
II	0.001	2.125	1.386-3.258
III	0.019	1.784	1.102-2.889
IV	<0.001	5.458	2.708-11.001
BCLC Classification	<0.001			<0.001
0 and A
B	0.001	2.040	1.341-3.105	<0.001	2.516	1.615-3.920
C and D	<0.001	4.368	2.238-8.524	<0.001	3.910	1.983-7.711

M: male; F: female; P: positive; N: negative; Y: yes; N: no; S: solitary; M: multiple; AFP: alpha fetoprotein; AJCC: American Joint Committee on Cancer; BCLC: Barcelona Clinic Liver Cancer