Table 2. Univariate and multivariate Cox regression analyses of clinicopathologic characteristics associated with survival in TCGA, GSE54467 and GSE65904 datasets.

TCGA dataset (n=374)	Univariate analysis
	unicox_p	HR	lower .95	upper .95	mutlicox_p	HR	lower .95	upper .95
Age	0.000	1.027	1.016	1.038	0.036	1.030	1.002	1.059
Gender	0.356	1.167	0.841	1.619	0.194	0.545	0.218	1.362
Race	0.042	2.450	1.035	5.800	0.871	1.529	0.009	260.783
Clark_level	0.000	1.812	1.415	2.321	0.519	1.250	0.635	2.462
Pathologic_M	0.041	2.223	1.034	4.779	0.011	13.499	1.803	101.036
Pathologic_N	0.019	1.512	1.071	2.133	0.486	1.627	0.414	6.384
Pathologic_T	0.001	1.566	1.216	2.016	0.259	1.954	0.610	6.254
Stage	0.001	1.669	1.229	2.267	0.859	0.874	0.198	3.864
Radiation_therapy	0.359	0.666	0.279	1.588	0.759	0.760	0.132	4.369
Metastatic_status	0.000	3.158	1.842	5.415	0.001	14.925	3.083	72.242
Tumor_status	0.000	9.007	5.107	15.884	0.000	15.483	4.972	48.217
Risk score	0.006	2.164	1.242	3.772	0.027	7.954	1.260	50.213
GSE65904 (n=214)
Age	0.797	0.998	0.985	1.012	0.778	0.998	0.984	1.012
Gender	0.169	1.335	0.885	2.016	0.296	1.248	0.824	1.891
Stage	0.348	1.140	0.867	1.500	0.558	1.087	0.822	1.439
Risk score	0.044	2.589	1.027	6.530	0.051	2.296	1.090	5.838
GSE54467 (n=79)
Age	0.025	1.021	1.003	1.039	0.009	1.024	1.006	1.043
Gender	0.998	1.001	0.568	1.764	0.933	0.976	0.550	1.730
Stage	0.168	1.257	0.908	1.741	0.079	1.357	0.965	1.908
Risk score	0.005	2.793	1.077	4.342	0.009	2.922	1.187	5.335