Table 1. Pearson’s correlation between mRNA levels of GDF11 and genes involved in lipid metabolism in our cohort of obese patients.
ALL | GDF11. vs. Col1A | GDF11. vs. FASN | GDF11. vs. PPARG | GDF11. vs. CPT1 | GDF11. vs. SREBP1 | GDF11. vs. PPARa |
Pearson r | 0.456 | 0.04332 | 0.527 | 0.3398 | 0.444 | 0.3189 |
P value | 0.0067 | 0.8078 | 0.0014 | 0.0493 | 0.0085 | 0.066 |
NAFLD | GDF11. vs. Col1A | GDF11. vs. FASN | GDF11. vs. PPARG | GDF11. vs. CPT1 | GDF11. vs. SREBP1 | GDF11. vs. PPARa |
Pearson r | -0.366 | -0.2601 | 0.3157 | -0.0023 | 0.3559 | 0.3276 |
P value | 0.1125 | 0.2682 | 0.1751 | 0.9922 | 0.1235 | 0.1585 |
NASH | GDF11. vs. Col1A | GDF11. vs. FASN | GDF11. vs. PPARG | GDF11. vs. CPT1 | GDF11. vs. SREBP1 | GDF11. vs. PPARa |
Pearson r | 0.7581 | 0.3356 | 0.6657 | 0.7411 | 0.5368 | 0.4897 |
P value | 0.0027 | 0.2623 | 0.013 | 0.0038 | 0.0585 | 0.0894 |
Analysis was carried out in all patients (n=33) or they were divided into two subgroups according to the presence NAFLD (n=20) or NASH (n=13).