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. 2020 Oct 18;12(20):19852–19866. doi: 10.18632/aging.104096

Figure 1.

Figure 1

Metformin blunts the global transcriptomic changes induced by PRT in human skeletal muscle. (A) Volcano plot of 2048 DEG (q-value < 0.01) with plaPRT between 16 weeks and baseline; (B) Volcano plot of 1435 DEG (q-value < 0.01) with metPRT intervention between 16 weeks and baseline; (C) Principal component analysis on DEG shared between plaPRT (orange) and metPRT (green) compared to baseline (blue); (D) Venn diagram showing an overlap of DEG common between plaPRT and metPRT vs baseline; (E) Correlation plot between the fold changes of DEG common between plaPRT and metPRT.