Fig 1.

The eye-of-the tiger sign on T2WI and iron topography on SWI at 3T MR imaging (NL, P11, P12, P13) and 7T MR imaging (P15). On T2WI, the round hyperintense center is reduced in size with extension of the surrounding hypointensity. A noticeable difference in signal hypointensity between the medial and lateral segments of the globus pallidus tends to be obscured with increasing age (arrows). The reduction of signal intensity in both the subthalamic nucleus and substantia nigra (P15, arrow) tends to be proportional to that of the GP. The fiber connections of the medial GP with the SN and STN are dramatically visualized (P13, open arrow). NL indicates healthy control; P11/P12/P13/P15, the number of patients in the On-line Table; y., years of age.