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. 2018 Dec;39(12):2256–2262. doi: 10.3174/ajnr.A5879

Table 2:

Characteristic brain MR imaging findings in WSS

Patient Sex/Age (yr) White Matter
Descriptive Features on MRI
Comments
Iron Deposition
Pituitary Atrophy Diffusion Restriction
Frontal Parietal Temporal Occipital Infratentorial Caudate Putamen RN/SN
1 F/18 + + + + +
2 M/19 + + Initial study showed no iron deposition
3 F/29 +++ +++ + + + Extension of iron deposition on follow-up study
4 F/38 ++ ++ + + + + + + Prominent perivascular spaces
5 F/35 + + + + Prominent perivascular spaces
6 F/37 +++ +++ + + + + Calcification of the dentate nucleus
7 M/45 +++ +++ + + + + + + Loss of corpus callosum volume
8 M/22 + + + +
9 M/24 + + + Prominent perivascular spaces
10 M/23 + + +
11 F/21 + + + +
12 M/16 + + + Prominent perivascular spaces
13 M/26 + + + + + + +
14 M/21 + +
15 M/20 + +
16 F/21 + + +
17 F/32 + + + + + +
18 F/22 +
19 F/35 +++ +++ + + + + + Pontine WM signal
20 M/21 + + +
21 F/27 + +
22 M/16 +
23 F/41 ++ ++ + + + + + +
24 M/37 ++ ++ + + + + + Dentate nucleus calcification
25 F/17 +
26 F/29 + + + + + Cerebellar WM signal

Note:—RN indicates red nucleus; SN, substantia nigra; −, absent; +, mild (predominantly scattered lesions or confluent periventricular); ++, moderate (patchy scattered); +++, severe (predominantly diffuse, vanishing lesions).