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. 2020 Apr 10;44(6):815–822. doi: 10.1016/j.jgr.2020.03.002

Fig. 5.

Fig. 5

GF2 aggravates alcoholic inflammatory response in IL-10 KO mice. Isolated liver MNCs from three groups (pair-fed, EtOH-fed, and EtOH + GF2) of IL-10 KO mice were subjected to flow cytometry or qRT-PCR analysis. (A) Frequencies of infiltrated macrophages (F4/80+CD11b+) and neutrophils (Gr1+CD11b+) were compared among groups. (B) Frequencies of hepatic lymphocytes such as CD4+ T cells, CD8+ T cells, NK cells, and NKT cells were assessed. (C) Frequencies of regulatory T cells (CD4+CD25+Foxp3+) were compared. (D) mRNA expression of diverse inflammation-related genes was evaluated in isolated liver MNCs of IL-10 KO mice. Data are expressed as the mean ± SEM. ∗p < 0.05, ∗∗p < 0.01 compared to the corresponding controls. The results represent three independent experiments. GF2 = ginsenoside F2; IL = interleukin; KO = knockout; MNCs = mononuclear cells; NK = natural killer; NKT = natural killer T.