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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Jul 18;5(11):1011–1018. doi: 10.1016/j.bpsc.2020.07.006

Fig. 2. Mediation model of DMN/SN dynamics at rest and changes in cue-induced subjective craving.

Fig. 2.

We applied mediation models where neural cue reactivities were the mediators for the relationship between either DMN or SN resting dynamics and changes in craving. A. In the model examining DMN dynamics, the path from total time spent in DMN at rest to AI (green in center brain template) cue reactivity to dACC (red in center brain template) cue reactivity to changes in craving yielded a significant indirect mediation effect, suggesting that AI and dACC together positively mediated the relationship between DMN resting dynamics and cue-induced craving. B. In the model examining SN dynamics, the path from total time spent in SN at rest to AI (green in center brain template) cue reactivity to dACC (red in center brain template) cue reactivity to changes in craving produced a significant indirect mediation effect, suggesting that AI and dACC significantly negatively mediated the relationship between SN resting dynamics and subjective cue-induced craving.