Table 3.

Multivariate analysis with Cox proportional hazard model for three survival endpoints: RFS, DMFS and MSS.

		RFS		DMFS		MSS
Cohorts	Predictors	Hazard ratio (HR)	P-value	Hazard ratio (HR)	P-value	Hazard ratio (HR)	P-value
Entire Cohort (n=831, excluded n=6) (Events: RFS: 164 ; DMFS: 110; MSS: 48)	Breslow thickness	1.20 (1.12 – 1.29)	<0.001	1.11 (1.03 – 1.19)	0.014	1.17 (1.07 – 1.28)	0.009
	Age	1.02 (1.00 – 1.03)	0.004	1.01 (1.00 – 1.02)	0.156	1.02 (1.00 – 1.04)	0.072
	Ulceration	1.56 (1.12 – 2.18)	0.010	1.71 (1.14 – 2.57)	0.011	1.64 (0.88 – 3.06)	0.125
	SLNb status	2.28 (1.61 – 3.24)	<0.001	2.10 (1.37 – 3.22)	0.001	1.74 (0.90 – 3.36)	0.102
	CP-GEP risk labels	2.40 (1.53 – 3.74)	<0.001	2.32 (1.35 – 3.97)	0.001	2.05 (0.93 – 4.54)	0.064
SLNb negative (n=633, excluded n=4) (Events: RFS: 89; DMFS: 59; MSS: 27)	Breslow thickness	1.31 (1.13 – 1.52)	0.002	1.39 (1.16 – 1.66)	0.002	1.53 (1.12 – 2.08)	0.018
	Age	1.01 (0.99 – 1.02)	0.220	1.00 (0.98 – 1.02)	0.752	1.03 (1.00 – 1.06)	0.073
	Ulceration	1.45 (0.90 – 2.34)	0.131	1.33 (0.74 – 2.41)	0.349	1.52 (0.65 – 3.53)	0.345
	CP-GEP risk labels	2.57 (1.53 – 4.34)	<0.001	2.72 (1.40 – 5.28)	0.002	1.98 (0.76 – 5.16)	0.152
Stages I-IIA (n=578, excluded n=2) (Events: RFS: 68; DMFS: 47; MSS: 21)	Breslow thickness	1.47 (1.07 – 2.02)	0.021	1.63 (1.13 – 2.37)	0.013	1.23 (0.67 – 2.27)	0.516
	Age	1.01 (0.99 – 1.03)	0.272	1.00 (0.98 – 1.02)	0.642	1.03 (1.00 – 1.06)	0.069
	Ulceration	0.95 (0.44 – 2.05)	0.900	1.15 (0.47 – 2.80)	0.765	1.20 (0.34 – 4.25)	0.783
	CP-GEP risk labels	2.27 (1.25 – 4.12)	0.006	2.29 (1.09 – 4.77)	0.025	2.27 (0.79 – 6.51)	0.123