Table 2.
Amino acid transport systems and their mediators and substrates
| System | SLC | cDNA | Substrates |
|---|---|---|---|
| Neutral amino acid transporters | |||
| Na+ dependent | |||
| A | SLC38A1 | SNAT1 | Gly, Ala, Ser, Cys, Gln, Asn, His, Met, Thr, Pro, Tyr, Val |
| SLC38A2 | SNAT2 | Gly, Pro, Ala, Ser, Cys, Gln, Asn, His, Met | |
| SLC38A4 | SNAT4 | Gly, Ala, Ser, Cys, Gln, Asn, Met | |
| SLC38A8 | FVH2 | Gln, Ala, Arg, His, Asp | |
| SLC38A10 | PP1744 | Gln, Ala, Glu, Asp, Ser | |
| Gly | SLC6A5 | GLYT2 | Gly |
| SLC6A9 | GLYT1 | Gly | |
| SLC6A18 | Xtrp2 | Gly, Ala | |
| B0 | SLC6A15 | SBAT1 | Pro, Met, BCAAs |
| SLC6A17 | NTT4 | Pro, Gly, Leu, Ala, Glu | |
| SLC6A19 | B0AT1 | neutral AA | |
| ASC | SLC1A4 | ASCT1 | Ala, Ser, Cys, Thr |
| SLC1A5 | ASCT2 | Ala, Ser, Cys, Thr, Gln, Asn | |
| N | SLC38A3 | SNAT3 | Gln, Asn, His |
| SLC38A5 | SNAT5 | Gln, Asn, His, Ser, Gly | |
| β | SLC6A6 | TauT | Tau, P-Ala |
| y+L | SLC7A6/SLC3A2 | y+LAT-2/4F2hc | Lys, Arg, Orn, Hys, Met, Leu |
| SLC7A7/SLC3A2 | y+LAT-1/4F2hc | Lys, Arg, Orn, Hys, Met, Leu, Ala, Cys | |
| Na+ independent | |||
| L | SLC7A5/SLC3A2 | LAT1/4F2hc | Leu, Hys, Met, Ile, Val, Phe,Tyr, Trp, Kyn |
| SLC7A8/SLC3A2 | LAT2/4F2hc | neutral AA | |
| SLC43A1 | LAT3 | Leu, Ile, Met, Phe, Val | |
| SLC43A2 | LAT4 | Leu, Ile, Met, Phe, Val | |
| asc | SLC7A10/SLC3A2 | Asc-1/4F2hc | Gly, Ala, Ser, Cys, Thr |
| T | SLC16A10 | TAT1 | Trp, Tyr, Phe |
| b0,+ | SLC7A9/SLC3A1 | BAT1/rBAT | Cys, dibasic and neutral amino acid |
| Basic amino acid transporters | |||
| Na+ dependent | |||
| B0,+ | SLC6A14 | ATB0,+ | Neutral and basic amino acid |
| Na+ independent | |||
| y+ | SLC7A1 | CAT1 | Lys, Arg, Orn |
| SLC7A2 | CAT2 | Lys, Arg, Orn | |
| SLC7A3 | CAT3 | Lys, Arg, Orn | |
| SLC7A4 | CAT4 | Basic amino acid | |
| y+L | Same as above | ||
| b0,+ | Same as above | ||
| Acidic amino acid transporters | |||
| Na+ dependent | |||
| X−AG | SLC1A1 | EAAT3 | Glu, Asp, Cys |
| SLC1A2 | EAAT2 | Glu, Asp | |
| SLC1A3 | EAAT1 | Glu, Asp | |
| SLC1A6 | EAAT4 | Glu, Asp | |
| SLC1A7 | EAAT5 | Glu, Asp | |
| Na+ independent | |||
| x−C | SLC7A11/SLC3A2 | xCT/4F2hc | Cys-Cys |
| Other transporters | |||
| Na+ dependent | |||
| IMINO | SLC6A20 | SIT1 | Pro, hydroxyproline |
| Na+ independent | |||
| Iminoglycine | SLC36A1 | PAT1 | Gly, Pro, Ala |
| SLC36A2 | PAT2 | Gly, Pro, Ala | |
| SLC36A4 | PAT4 | Pro, Trp, Ala | |