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. Author manuscript; available in PMC: 2021 Mar 7.
Published in final edited form as: Nat Biomed Eng. 2020 Sep 7;4(11):1053–1062. doi: 10.1038/s41551-020-00606-8

Fig 6 |. Hypotonic gelling formulation (12% Hypo) is indistinguishable from no treatment (Untreated) with twice-daily dosing for 5 weeks in rabbits.

Fig 6 |

12% Hypo was compared to an isotonic formulation (12% Iso), isotonic balanced salt solution (BSS) and no treatment (Untreated) with bilateral administration of twice-daily dosing for 5 weeks in rabbits. Ocular surface damage, as assessed by (a) lissamine green staining and scoring and (b) counting the number of blinks in a 3 min period 3 h after the first dose on a given day, as well as (C) H&E staining of cornea tissues collected at 5 weeks (n = 3 independent eyes and one image was obtained per group), was indistinguishable across all groups.