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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Trace Elem Med Biol. 2020 Sep 19;62:126648. doi: 10.1016/j.jtemb.2020.126648

Figure 1.

Figure 1.

Representative CT images of the mouse brain and DEC-CT operational model diagram. (A) representative 3D rendering of a mouse brain and approximate slice location shown in panels B-D (black plane). (B) CT image prior to DCE injection, (C) CT image at peak contrast concentration, (D) region mask of mouse brain. (E) DCE-CT Operational Model Diagram. It describes the compartments and rate constants which describe the mass balance of IsoVue 370, which is a cell impermeant diffusion limited CT contrast agent. IsoVue 370 (blue ellipse) introduced into the central blood compartment via tail vein (red ellipse) which distributes to the brain compartment (orange ellipse) and back to the central compartment based on the permeability surface area product.