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. Author manuscript; available in PMC: 2021 Nov 11.
Published before final editing as: J Trace Elem Med Biol. 2020 May 11;61:126546. doi: 10.1016/j.jtemb.2020.126546

Fig. 2.

Fig. 2.

Effects of BIX02189 pre-treatment on Mn cytotoxicity in MN9D cells. Cells were pre-treated with 10 μM BIX02189 for 1.5 h, followed by exposure to Mn at 400, 800 or 1200 μM for 24 h. The cells were then subjected to the apoptosis assay. Data were normalized by the optical density at 0μM Mn (control) as the % increase of apoptosis. Each data point represent mean ± SEM, n = 3-5 of independent experiments. *: p < 0.05 as compared to control (0 μM Mn). #: p < 0.05 as compared to groups with only Mn exposure at the same dose level.