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. 2020 Aug 28;184(3):723–731. doi: 10.1007/s10549-020-05881-2

Table 3.

Detection rate and size estimation in invasive tumors

Lesions US FFDM CESM MRI
163 157 161 163
(a) Detection rate versus pathology
 Lesions detected

160

98.2% (94.7–99.6%)

135

86.0% (79.6–91.0%)

158

98.1% (94.7–99.6%)

162

99.4% (96.6–100%)

 Performance CESM 1.00 < 0.0001 0.50
US FFDM CESM MRI
(b) Lesion size versus pathology
 Negative

3

1.8% (0.4–5.3%)

22

14.0% (9.0–20.4%)

3

1.9% (0.4–5.4%)

1

0.6% (0.0–3.4%)

 Performance CESM* 1.00  < 0.0001 - 0.50
 Underestimated

32

19.6% (13.8–26.6%)

38

24.2% (17.7–31.7%)

28

17.4% (11.9–24.1%)

11

6.7 (3.4–11.8%)

 Performance CESM* 0.56 0.04 0.0005
 Concordant

101

62.0% (54.0–69.4)

71

45.2% (37.3–53.4%)

104

64.6% (56.7–72.0)

114

69.9% (62.3–78.9%)

 Performance CESM* 0.56  < 0.0001 0.28
 Overestimated

27

16.6% (11.2–23.2%)

26

16.6% (11.1–23.3%)

26

16.2% (10.8–22.8%)

37

22.7% (16.5–29.9%)

 Performance CESM* 1.00 1.00 0.02

FFDM was not evaluable for 6 patients, CESM for 2 patients and MRI for 1 patient

FFDM full field digital mammography, CESM contrast enhanced spectral mammography, US ultrasound, MRI magnetic resonance imaging

The performance of CESM with respect to US, MRI and FFDM is evaluated with McNemar Test p-value