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. 2020 Oct 10;94(12):4055–4065. doi: 10.1007/s00204-020-02927-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Concentration–response curves of AChE activity following exposure to eight different compounds in electric eel. a The OP parent compounds (CPF, DZN, PM; open symbols) do not show any AChE inhibition. The oxon metabolites of the OPs (CPO, DZO, PMO; closed symbols) show inhibition of AChE. b The two carbamates (PI and RI) also show inhibition of AChE. Data are presented as mean ± SD of 3–4 independent experiments