Table 2.

Significantly altered miRNAs in ACC of MDD group (p≥ 0.05)

miRNA	miRBase ACC No.	Fold change	p-value	Chromosomal location
Up-regulated
hsa-miR-6077	MIMAT0023702	2.59	1.9E-05	chr1: 148388282–148388363 [+]
hsa-miR-4632-3p	MIMAT0019688	2.69	2.2E-05	chr1: 12191713–12191773 [+]
hsa-miR-6789-3p	MIMAT0027479	2.49	0.00017	chr19: 2235829–2235926 [−]
hsa-miR-648	MIMAT0003318	2.41	0.00025	chr22: 17980868–17980961 [−]
hsa-miR-4498	MIMAT0019033	2.83	0.00049	chr12: 120155434–120155499 [−]
hsa-miR-6084	MIMAT0023709	2.22	0.0007	chr1: 20633679–20633788 [+]
hsa-miR-4433a-3p	MIMAT0018949	2.15	0.00095	chr2: 64340759–64340839 [+]
hsa-miR-4638-5p	MIMAT0019695	2.04	0.00128	chr5: 181222566–181222633 [−]
hsa-miR-4258	MIMAT0016879	2.39	0.00142	chr1: 154975693–154975783 [+]
hsa-miR-6850-5p	MIMAT0027600	2.01	0.00168	chr8: 144791931–144791991 [−]
hsa-miR-4510	MIMAT0019047	1.62	0.00171	chr15: 35926856–35926923 [+]
hsa-miR-3651	MIMAT0018071	2.47	0.00173	chr9: 92292458–92292547 [−]
hsa-miR-4497	MIMAT0019032	2.73	0.00243	chr12: 109833348–109833436 [+]
hsa-miR-668-5p	MIMAT0026636	2.62	0.00244	chr14: 101055258–101055323 [+]
hsa-miR-6800-3p	MIMAT0027501	1.72	0.00291	chr19: 49832018–49832099 [+]
hsa-miR-7108-3p	MIMAT0028114	2.81	0.00474	chr19: 2434914–2435000 [−]
hsa-miR-4761-3p	MIMAT0019909	2.96	0.00478	chr22: 19963753–19963834 [+]
hsa-miR-4426	MIMAT0018941	2.56	0.00509	chr1: 192716328–192716390 [+]
hsa-miR-4720-3p	MIMAT0019834	1.93	0.00573	chr16: 81385018–81385093 [+]
hsa-miR-4281	MIMAT0016907	1.78	0.00656	chr5: 176629439–176629500 [−]
hsa-miR-1273h-3p	MIMAT0030416	1.36	0.0066	chr16: 24203116–24203231 [+]
hsa-miR-4736	MIMAT0019862	1.84	0.00694	chr17: 58335976–58336022 [−]
hsa-miR-3155a	MIMAT0015029	1.49	0.00736	chr10: 6152196–6152277 [+]
hsa-miR-1227-5p	MIMAT0022941	1.81	0.00751	chr19: 2234062–2234149 [−]
hsa-miR-6802-5p	MIMAT0027504	1.5	0.00762	chr19: 55239912–55239976 [−]
hsa-miR-572	MIMAT0003237	2.21	0.00776	chr4: 11368827–11368921 [+]
hsa-miR-1470	MIMAT0007348	2.5	0.00876	chr19: 15449548–15449608 [+]
hsa-miR-520f-3p	MIMAT0002830	2.11	0.01011	chr19: 53682159–53682245 [+]
hsa-miR-92b-3p	MIMAT0003218	1.36	0.01019	chr1: 155195177–155195272 [+]
hsa-miR-5572	MIMAT0022260	1.68	0.01052	chr15: 80581103–80581239 [+]
hsa-miR-4746-3p	MIMAT0019881	2.18	0.01059	chr19: 4445978–4446048 [+]
hsa-miR-550b-2-5p	MIMAT0022737	1.99	0.01082	chr7: 30289794–30289890 [−]
hsa-miR-518e-5p	MIMAT0005450	1.84	0.01137	chr19: 53729838–53729925 [+]
hsa-miR-6781-5p	MIMAT0027462	1.66	0.01184	chr17: 42823880–42823943 [−]
hsa-miR-6890-3p	MIMAT0027681	1.91	0.01185	chr3: 49099854–49099914 [−]
hsa-miR-760	MIMAT0004957	1.34	0.01196	chr1: 93846832–93846911 [+]
hsa-miR-516a-3p	MIMAT0006778	1.75	0.01338	chr19: 53756741–53756830 [+]
hsa-miR-4695-5p	MIMAT0019788	1.99	0.01347	chr1: 18883202–18883275 [−]
hsa-miR-501-3p	MIMAT0004774	1.34	0.014	chrX: 50009722–50009805 [+]
hsa-miR-1180-5p	MIMAT0026735	1.6	0.01427	chr17: 19344506–19344574 [−]
hsa-miR-4728-3p	MIMAT0019850	1.86	0.01456	chr17: 39726495–39726561 [+]
hsa-miR-523-5p	MIMAT0005449	1.79	0.01576	chr19: 53698385–53698471 [+]
hsa-miR-1193	MIMAT0015049	2.45	0.01676	chr14: 101030052–101030129 [+]
hsa-miR-4318	MIMAT0016869	1.84	0.01778	chr18: 37657135–37657215 [+]
hsa-miR-5580-5p	MIMAT0022273	1.82	0.01786	chr14: 53948427–53948484 [−]
hsa-miR-7112-5p	MIMAT0028121	1.75	0.01981	chr8: 144262673–144262737 [−]
hsa-miR-6805-3p	MIMAT0027511	1.52	0.02005	chr19: 55388181–55388242 [+]
hsa-miR-5587-5p	MIMAT0022289	1.46	0.02055	chr16: 535316–535368 [+]
hsa-miR-6851-5p	MIMAT0027602	1.61	0.02114	chr9: 33467869–33467935 [−]
hsa-miR-6814-3p	MIMAT0027529	1.53	0.02122	chr21: 41746772–41746841 [−]
hsa-miR-4663	MIMAT0019735	1.56	0.02128	chr8: 123215788–123215863 [−]
hsa-miR-6075	MIMAT0023700	2.54	0.02134	chr5: 1510762–1510856 [−]
hsa-miR-1343-3p	MIMAT0019776	1.37	0.02178	chr11: 34941837–34941920 [+]
hsa-miR-6737-5p	MIMAT0027375	2.61	0.2188	chr1: 153962351–153962420 [−]
hsa-miR-6879-3p	MIMAT0027659	1.52	0.0229	chr11: 65018505–65018570 [+]
hsa-miR-4701-3p	MIMAT0019799	235	0.02293	chr12: 48771975–48772037 [−]
hsa-miR-92b-5p	MIMAT0004792	1.6	0.02334	chr1: 155195177–155195272 [+]
hsa-miR-6753-5p	MIMAT0027406	1.7	0.02367	chr11: 68044794–68044957 [+]
hsa-miR-4485-5p	MIMAT0032116	1.55	0.02503	chr11: 10508270–10508326 [−]
hsa-miR-6769b-5p	MIMAT0027620	1.65	0.02522	chr1: 206474803–206474864 [+]
hsa-miR-519b-3p	MIMAT0002837	1.84	0.02561	chr19: 53695213–53695293 [+]
hsa-miR-4430	MIMAT0018945	1.66	0.02604	chr2: 33418516–33418564 [+]
hsa-miR-6511b-5p	MIMAT0025847	1.38	0.0264	chr16: 2106669–2106753 [−]
hsa-miR-595	MIMAT0003263	1.72	0.02696	chr7: 158532718–158532813 [−]
hsa-miR-3591-5p		1.82	0.02726
hsa-miR-6892-5p	MIMAT0027684	1.48	0.0278	chr7: 143382686–143382800 [+]
hsa-miR-6769a-5p	MIMAT0027438	1.66	0.02784	chr16: 4671318–4671390 [+]
hsa-miR-6815-3p	MIMAT0027531	1.51	0.02888	chr21: 45478266–45478326 [+]
hsa-miR-6082	MIMAT0023707	1.6	0.02979	chr4: 171186184–171186292 [+]
hsa-miR-4466	MIMAT0018993	1.8	0.03022	chr6: 156779678–156779731 [−]
hsa-miR-4758-5p	MIMAT0019903	1.56	0.0304	chr20: 62332487–62332557 [−]
hsa-miR-622	MIMAT0003291	1.43	0.03112	chr13: 90231182–90231277 [+]
hsa-miR-6851-3p	MIMAT0027603	1.6	0.03117	chr9: 33467869–33467935 [−]
hsa-miR-521	MIMAT0002854	1.6	0.03178
hsa-miR-521-1				chr19: 53748636–53748722 [+]
hsa-miR-521-2				chr19: 53716594–53716680 [+]
hsa-miR-636	MIMAT0003306	1.73	0.03187	chr17: 76736450–76736548 [−]
hsa-let-7c-3p	MIMAT0026472	1.12	0.03194	chr21: 16539828–16539911 [+]
hsa-miR-6810-3p	MIMAT0027521	1.46	0.03235	chr2: 218341911–218341980 [+]
hsa-miR-1247-5p	MIMAT0005899	1.58	0.03266	chr14: 101560287–101560422 [−]
hsa-miR-3648	MIMAT0018068	1.77	0.0332
hsa-mir-3648-1				chr21: 8208473–8208652 [+]
hsa-mir-3648-2				chr21: 8986999–8987178 [+]
hsa-miR-484	MIMAT0002174	1.31	0.03341	chr16: 15643294–15643372 [+]
hsa-miR-3621	MIMAT0018002	1.8	0.03348	chr9: 137169186–137169270 [−]
hsa-let-7e-5p	MIMAT0000066	1.18	0.03408	chr19: 51692786–51692864 [+]
hsa-miR-519d-3p	MIMAT0002853	1.43	0.03453	chr19: 53713347–53713434 [+]
hsa-miR-486-3p	MIMAT0004762	1.43	0.03481	chr8: 41660441–41660508 [−]
hsa-miR-3189-3p	MIMAT0015071	1.48	0.03544	chr19: 18386562–18386634 [+]
hsa-miR-5189-5p	MIMAT0021120	1.69	0.03563	chr16: 88468918–88469031 [+]
hsa-miR-4522	MIMAT0019060	1.44	0.03575	chr17: 27293910–27293996 [−]
hsa-miR-302c-5p	MIMAT0000716	1.48	0.03583	chr4: 112648363–112648430 [−]
hsa-miR-328-3p	MIMAT0000752	1.44	0.03667	chr16: 67202321–67202395 [−]
hsa-miR-1-5p	MIMAT0031892	1.22	0.03697	chr20: 62554306–62554376 [+]
hsa-miR-1234-3p	MIMAT0005589	1.39	0.03734	chr8: 144400086–144400165 [−]
hsa-miR-6826-3p	MIMAT0027553	1.4	0.03748	chr3: 129272146–129272243 [+]
hsa-miR-378c	MIMAT0016847	1.15	0.03837	chr10: 130962588–130962668 [−]
hsa-miR-30d-5p	MIMAT0000245	1.11	0.03859	chr8: 134804876–134804945 [−]
hsa-miR-7156-3p	MIMAT0028223	1.32	0.03873	chr1: 77060143–77060202 [+]
hsa-miR-519e-5p	MIMAT0002828	1.42	0.03896	chr19: 53679940–53680023 [+]
hsa-miR-6869-5p	MIMAT0027638	1.57	0.03987	chr20: 1392900–1392961 [−]
hsa-miR-3689f	MIMAT0019010	1.74	0.04079	chr9: 134850742–134850807 [−]
hsa-miR-4512	MIMAT0019049	1.55	0.04117	chr15: 66496958–66497034 [−]
hsa-miR-6857-5p	MIMAT0027614	1.4	0.04123	chrX: 53405673–53405765 [−]
hsa-miR-6889-3p	MIMAT0027679	1.47	0.04153	chr22: 41252992–41253050 [−]
hsa-miR-6131	MIMAT0024615	1.37	0.04303	chr5: 10478037–10478145 [+]
hsa-miR-6510-5p	MIMAT0025476	1.53	0.04315	chr17: 41517164–41517217 [−]
hsa-miR-4505	MIMAT0019041	1.66	0.04334	chr14: 73758747–73758819 [+]
hsa-miR-4685-3p	MIMAT0019772	1.4	0.04387	chr10: 98431292–98431360 [−]
hsa-miR-4530	MIMAT0019069	1.82	0.04423	chr19: 39409623–39409678 [−]
hsa-miR-6794-5p	MIMAT0027488	1.56	0.04427	chr19: 12852260–12852327 [+]
hsa-miR-125b-2-3p	MIMAT0004603	1.17	0.04465	chr21: 16590237–16590325 [+]
hsa-miR-4538	MIMAT0019081	1.54	0.04479	chr14: 105858165–105858242 [−]
hsa-miR-663b	MIMAT0005867	1.8	0.0453	chr2: 132256966–132257080 [−]
hsa-miR-3609	MIMAT0017986	1.42	0.04669	chr7: 98881650–98881729 [+]
hsa-miR-2861	MIMAT0013802	1.76	0.04701	chr9: 127785918–127786007 [+]
hsa-miR-4783-5p	MIMAT0019946	1.4	0.04721	chr2: 127423537–127423618 [−]
hsa-miR-671-3p	MIMAT0004819	1.26	0.04791	chr7: 151238421–151238538 [+]
hsa-miR-3928-5p	MIMAT0027037	1.19	0.04812	chr22: 31160062–31160119 [−]
hsa-miR-6821-5p	MIMAT0027542	1.61	0.04932	chr22: 49962866–49962939 [+]
hsa-miR-6853-3p	MIMAT0027607	1.24	0.0499	chr9: 35732922–35732995 [+]
Downregulated
hsa-miR-136-5p	MIMAT0000448	0.73	0.00047	chr14: 100884702–100884783 [+]
hsa-miR-551b-3p	MIMAT0003233	0.73	0.00117	chr3: 168551854–168551949 [+]
hsa-miR-367-3p	MIMAT0000719	0.45	0.00137	chr4: 112647874–112647941 [−]
hsa-miR-5590-5p	MIMAT0022299	0.46	0.00221	chr2: 134857820–134857873 [+]
hsa-miR-337-5p	MIMAT0004695	0.84	0.00244	chr14: 100874493–100874585 [+]
hsa-miR-1251-5p	MIMAT0005903	0.81	0.00248	chr12: 97491909–97491978 [+]
hsa-miR-543	MIMAT0004954	0.83	0.00361	chr14: 101031987–101032064 [+]
hsa-miR-138-5p	MIMAT0000430	0.8	0.00399	chr16: 56858518–56858601 [+]
hsa-miR-20b-3p	MIMAT0004752	0.47	0.00427	chrX: 134169809–134169877 [−]
hsa-miR-495-5p	MIMAT0022924	0.85	0.00475	chr14: 101033755–101033836 [+]
hsa-miR-6808-3p	MIMAT0027517	0.62	0.00586	chr1: 1339650–1339708 [−]
hsa-miR-4705	MIMAT0019805	0.88	0.00765	chr13: 102045934–102046004 [−]
hsa-miR-376a-3p	MIMAT0000729	0.81	0.00766	chr14: 101040782–101040849 [+]
hsa-miR-4796-3p	MIMAT0019971	0.73	0.00775	chr3: 114743445–114743525 [−]
hsa-miR-495-3p	MIMAT0002817	0.75	0.01027	chr14: 101033755–101033836 [+]
hsa-miR-154-5p	MIMAT0000452	0.84	0.01082	chr14: 101059755–101059838 [+]
hsa-miR-496	MIMAT0002818	0.84	0.01097	chr14: 101060573–101060674 [+]
hsa-miR-548ar-3p	MIMAT0022266	0.46	0.01173	chr13: 114244505–114244561 [+]
hsa-miR-670-3p	MIMAT0026640	0.75	0.01195	chr11: 43559656–43559753 [+]
hsa-miR-488-3p	MIMAT0004763	0.85	0.01201	chr1: 177029363–177029445 [−]
hsa-miR-29b-2-5p	MIMAT0004515	0.9	0.01285	chr1: 207802443–207802523 [−]
hsa-miR-497-5p	MIMAT0002820	0.86	0.01297	chr17: 7017911–7018022 [−]
hsa-miR-335-5p	MIMAT0000765	0.87	0.01304	chr7: 130496111–130496204 [+]
hsa-miR-487a-3p	MIMAT0002178	0.82	0.01611	chr14: 101052446–101052525 [+]
hsa-miR-544a	MIMAT0003164	0.8	0.01635	chr14: 101048658–101048748 [+]
hsa-miR-342-5p	MIMAT0004694	0.89	0.01789	chr14: 100109655–100109753 [+]
hsa-miR-1197	MIMAT0005955	0.82	0.01812	chr14: 101025564–101025651 [+]
hsa-miR-153-5p	MIMAT0026480	0.81	0.01966	chr7: 157574336–157574422 [−]
hsa-miR-6844	MIMAT0027589	0.78	0.0209	chr8: 124508515–124508576 [−]
hsa-miR-758-3p	MIMAT0003879	0.85	0.02115	chr14: 101026020–101026107 [+]
hsa-miR-22-5p	MIMAT0004495	0.87	0.02205	chr17: 1713903–1713987 [−]
hsa-miR-29b-3p	MIMAT0000100	0.85	0.02327	chr7: 130877459–130877539 [−]
hsa-miR-377-3p	MIMAT0000730	0.83	0.02501	chr14: 101062050–101062118 [+]
hsa-miR-153-3p	MIMAT0000439	0.8	0.02614	chr2: 219294111–219294200 [−]
hsa-miR-2277-5p	MIMAT0017352	0.9	0.02674	chr5: 93620696–93620788 [−]
hsa-miR-9-3p	MIMAT0000442	0.9	0.02713	chr1: 156420341–156420429 [−]
hsa-miR-1307-5p	MIMAT0022727	0.83	0.03086	chr10: 103394253–103394401 [−]
hsa-miR-548a-3p	MIMAT0003251	0.72	0.03186	chr6: 18571784–18571880 [+]
hsa-miR-494-3p	MIMAT0002816	0.9	0.03362	chr14: 101029634–101029714 [+]
hsa-miR-22-3p	MIMAT0000077	0.89	0.03656	chr17: 1713903–1713987 [−]
hsa-miR-3689a-5p	MIMAT0018117	0.43	0.03897	chr9: 134849487–134849564 [−]
hsa-miR-146a-5p	MIMAT0000449	0.9	0.04076	chr5: 160485352–160485450 [+]
hsa-miR-4477b	MIMAT0019005	0.81	0.04126	chr9: 41233755–41233835 [−], chr9: 63819574–63819654 [+]
hsa-miR-582-3p	MIMAT0004797	0.88	0.04397	chr5: 59703606–59703703 [−]
hsa-miR-7-1-3p	MIMAT0004553	0.9	0.04513	chr9: 83969748–83969857 [−]
hsa-miR-376c-3p	MIMAT0000720	0.83	0.04613	chr14: 101039690–101039755 [+]
hsa-miR-135b-5p	MIMAT0000758	0.85	0.04615	chr1: 205448302–205448398 [−]
hsa-miR-376a-5p	MIMAT0003386	0.86	0.04712	chr14: 101040782–101040849 [+]
hsa-miR-128-2-5p	MIMAT0031095	0.62	0.04776	chr3: 35744476–35744559 [+]
hsa-miR-376c-5p	MIMAT0022861	0.85	0.04836	chr14: 101039690–101039755 [+]
hsa-miR-5582-3p	MIMAT0022280	0.63	0.04923	chr11: 46753125–46753192 [−]
hsa-miR-548ac	MIMAT0018938	0.53	0.04978	chr1: 116560024–116560111 [−]
hsa-miR-3182	MIMAT0015062	0.7	0.04988	chr16: 83508346–83508408 [+]
hsa-miR-548a-5p	MIMAT0004803	0.72	0.04997	chr8: 104484369–104484465 [−]

Bold face letter miRNAs show fold change >2.0 (upregulated) or <0.5 (downregulated)