Table 3.

KEGG pathway results from extremely upregulated 24 miRNAs (fold change cut off >2.0)

Gene Set	Description	Enrichment ratio	p-value	FDR	Candidate genes
hsa04720	Long-term potentiation	3.4039	0.00016382	0.0055154	ADCY1, CALM1, GRIA2, GRIN1, MAPK1, PPP1CB, PRKCA, PRKCB, PRKCG, RAP1A, RPS6KA1, RPS6KA3
hsa05220	Chronic myeloid leukemia	3.2509	0.00014340	0.0055154	CBL, CDKN1B, GAB2, GADD45A, HDAC2, MAPK1, MYC, NFKB1, NFKBIA, PIK3CD, POLK, RELA, SHC4
hsa04550	Signaling pathways regulating pluripotency of stem cells	2.7345	0.000035245	0.0041494	ACVR1B, ACVR2B, BMPR1A, FGFR2, FZD10, FZD3, FZD5, IGF1, IL6ST, KAT6A, MAPK1, MEIS1, MYC, ONECUT1, OTX1, PCGF5, PIK3CD, SMAD9, WNT3A, ZFHX3
hsa04722	Neurotrophin signaling pathway	2.7150	0.00014818	0.0055154	ARHGDIA, CALM1, IRAK2, IRAK4, MAPK1, NFKB1, NFKBIA, NTRK2, NTRK3, PIK3CD, RAN1A, RELA, RPS6KA1, RPS6KA3, RPS6KA5, SHC4, TP73
hsa04360	Axon guidance	2.4978	0.000040804	0.0041494	ARHGEF12, CFL2, CXCL12, DPYSL5, FZD3, GNAI2, MAPK1, NRP1, PAK2, PAK3, PARD6G, PIK3CD, PLXNA1, PLXNC1, PRKCA, RASA1, ROBO2, ROCK1, SEMA3A, SEMA3C, SEMA5A, SRGAP2, SRGAP3
hsa04014	Ras signaling pathway	2.3756	0.000010929	0.0035628	ARF6, CALM1, CSF1, FGF1, FGFR2, GAB2, GNGT2, GRIN1, IGF1, KIT, KSR2, MAPK1, NFKB1, NTRK2, PAK2, PAK3, PIK3CD, PRKCA, PRKCB, PRKCG, RAB5B, RAP1A, RASAL2, RASGRF2, RELA, SHC4, STK4, TEK
hsa05202	Transcriptional misregulation in cancer	2.3501	0.00010641	0.0055154	AFF1, CDKN1B, FOXO1, GADD45A, H3F3B, HDAC2, HMGA2, IGF1, IL2RB, KLF3, MEF2C, MEIS1, MMP3, MPO, MYC
hsa04144	Endocytosis	2.1030	0.00018487	0.0055154	AGAP1, ARF6, ARFGEF1, CAPZA1, CBL, CHMP4C, CHMP7, CYTH4, FGFR2, IL2RB, IQSEC2, KIF5C, NEDD4, PARD6G, PIP5K1C, PML, PRKCI, RAB10, RAB11FIP4, RAB31, RAB35, RAB5B, RABEP1, SH3GLB1, SMURF1, SNX12, STAM2
hsa04010	MAPK signaling pathway	1.9971	0.00016207	0.0055154	CACNA1E, CACNB4, CSF1, DUSP16, FGF1, FGFR2, CADD45A, IGF1, IRAK4, KIT, MAPK1, MEF2C, MKNK2, MYC, NFKB1, NLK, NTRK2, PAK2, PRKCA, PRKCB, PRKCG, RAP1A, RASA1, RASGRF2, RELA, RPS6KA1, RPS6KA3, RPS6KA5, STK4, TAOK1, TEK
hsa05200	Pathways in cancer	1.7704	0.000050912	0.0041494	ADCY1, ADCY2, ARHGEF12, ARNT, CALM1, CBL, CCDC6, CDKN1B, COL4A2, CXCL12, DLL4, EDNRB, ESR1, FGF1, FGFR2, FOXO1, FZD10, FZD3, FZD5, GADD45Am GNAI2, GNGT2, HDAC2, HEY2, IGF1, IL2RB, IL6ST, ITGA2, KIT, LAMC3, MAPK1, MYC, NFKB1, NFKBIA, NOTCH2, PIK3CD, PML, POLK, PRKCA, PRLCB, PRKCG, RELA, ROCK1, RPS6KA5, SP1, STK4, TPM3, TRAF4, WNT3A