Skip to main content
. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Cardiothorac Vasc Anesth. 2020 May 11;34(12):3314–3320. doi: 10.1053/j.jvca.2020.04.017

Table 2.

Association of APOL1 Risk Genotype With %ΔCr in the Analysis Dataset

Model Variable Mean Difference (SE) 95% CI p Value VIF
Univariate APOL1 risk (recessive) 39.5 (13.7) 12.28–66.71 0.005 ---
Multivariable APOL1 risk (recessive) 44.8 (15.8) 13.29–76.27 0.006 1.02
Sex (male) −17.6 (8.1) − 33.72 to −1.51 0.03 1.01
Cross-clamp time 0.11 (0.1) − 0.02 to 0.31 0.09 1.08
Ejection fraction − 0.5 (0.3) −0.93 to 0.14 0.15 1.07

NOTE. Because the outcome is %ΔCr and APOL1 is coded as a recessive model, the mean difference is the beta-coefficient estimate of APOL1. The interpretation of the APOL1 effect is that the rare homozygous APOL1 risk genotype has an increase of 44.8%ΔCr compared with the APOL1 control genotype.

Abbreviations: APOL1, apolipoprotein L1; %ΔCr, peak serum creatinine rise after surgery relative to preoperative creatinine; CI, confidence interval; SE, xxxx; VIF, variance inflation factor.