Table 2.
Model | Variable | Mean Difference (SE) | 95% CI | p Value | VIF |
---|---|---|---|---|---|
Univariate | APOL1 risk (recessive) | 39.5 (13.7) | 12.28–66.71 | 0.005 | --- |
Multivariable | APOL1 risk (recessive) | 44.8 (15.8) | 13.29–76.27 | 0.006 | 1.02 |
Sex (male) | −17.6 (8.1) | − 33.72 to −1.51 | 0.03 | 1.01 | |
Cross-clamp time | 0.11 (0.1) | − 0.02 to 0.31 | 0.09 | 1.08 | |
Ejection fraction | − 0.5 (0.3) | −0.93 to 0.14 | 0.15 | 1.07 |
NOTE. Because the outcome is %ΔCr and APOL1 is coded as a recessive model, the mean difference is the beta-coefficient estimate of APOL1. The interpretation of the APOL1 effect is that the rare homozygous APOL1 risk genotype has an increase of 44.8%ΔCr compared with the APOL1 control genotype.
Abbreviations: APOL1, apolipoprotein L1; %ΔCr, peak serum creatinine rise after surgery relative to preoperative creatinine; CI, confidence interval; SE, xxxx; VIF, variance inflation factor.