Table 2.
Number of observations and p-values for overall dose and day effects for liver function tests and complete blood counts.
| LFT and CBC components | Total # of observations analyzed (# rabbits) | p-value for overall dose effect* | p-value for overall day effect |
|---|---|---|---|
| AST | 25 (5) | 0.0957 | 0.0074 |
| ALT | 25 (5) | 0.0535 | 0.0001 |
| Neutrophils | 30(5) | 0.0537 | <0.0001 |
| WBC | 33 (6) | 0.5200 | 0.0107 |
| RBC | 34 (6) | 0.1729 | 0.1187 |
| Platelets | 34 (6) | 0.5064 | <0.0001 |
*
The dose effect in the statistical model refers to the combined effects of microspheres and drug