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. Author manuscript; available in PMC: 2021 Sep 24.
Published in final edited form as: Curr Opin Virol. 2020 Sep 24;43:59–70. doi: 10.1016/j.coviro.2020.08.006

Fig. 2. In vitro, animal models, and clinical studies showing protective and enhancing interactions between DENV → DENV, DENV → ZIKV, and ZIKV → DENV.

Fig. 2.

Columns show studies conducted in in vitro assays, mouse models, non-human primate challenge studies, human epidemiological and clinical studies, and human pregnancy/infant studies. Rows show the sequence of infecting viruses: primary DENV followed by secondary DENV infection with a different serotype, primary DENV infection followed by secondary ZIKV infection, and primary ZIKV infection followed by secondary DENV infection. Green “P” indicates protection, red “E” indicates enhancement, and question marks indicate unknown relationships.