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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Urol. 2020 Jun 18;204(6):1173–1179. doi: 10.1097/JU.0000000000001199

Table 1.

Patient demographics and disease characteristics at baseline

Derivation atezolizumab data (n = 405) Validation
avelumab data (n = 242) durvalumab data (n = 198)
Age (years)
Mean (sd) 65.5, (9.9) 67.6 (10.61) 66.1 (9.40)
Median (min; max) 66 (32; 89) 68 (30; 89) 67 (34; 88)
Gender
Female 92 (22.7%) 67 (27.7%) 56 (28.3%)
Male 313 (77.3%) 175 (72.3%) 142 (71.7%)
NLR (Neutrophil / Lymphocyte Ratio)
Mean (sd) 5.1 (4.6) 5.7 (3.0) 6.0 (7.3)
Median (min; max) 3.9 (1.0;69.0) 4.2 (0.5; 30.7) 3.9 (0.9; 72.3)
Missing n (%) --- --- 4 (2.0%)
ECOG-Performance Status
0 154 (38.0%) 84 (34.7%) 63 (31.8%)
≥1 251 (62.0%) 158 (65.3%) 135 (68.2%)
Serum LDH (U/L)
Mean (sd) 289.9 (241.2) 282.6 (292.8) 319.1 (361.2)
Median (min; max) 215 (96; 2357) 208 (6.4; 4000) 229.0 (89; 4256)
Missing n (%) 19 (4.7%) 7 (2.9%) 6 (3.0%)
Platelet counts (109/L)
Mean (sd) 253.6 (99.2) 265.8 (116.1) 263.2 (101.5)
Median (min; max) 238 (101; 718) 240.5 (95; 668) 241 (108; 620)
Missing n (%) --- --- 4 (2.0%)
Location of Metastasis*
Liver 131 (32.4%) 83 (34.3%) 70 (35.4%)
Visceral 186 (45.9%) 104 (43%) 132 (66.7%)
Soft tissue/lymph node 88 (21.7%) 55 (22.7%) 24 (12.1%)
Serum Albumin (gm/L)
Mean (sd) 38.8 (5.0) 38.5 (4.8) 37 (5)
Median (min; max) 39 (25; 50) 39 (19; 50) 39 (20; 46)
Missing n (%) --- --- 3 (1.5%)
Hemoglobin (gm/L)
Mean (sd) 117.8 (18.0) 115.8 (15.9) 113 (15)
Median (min; max) 117 (77; 171) 114 (90; 156) 112 (80; 153)
Missing n (%) --- --- 4 (2.0%)
Number of previous agents
≤ 1 194 (47.9%) 80 (33.1%) 125 (63.1%)
2 107 (26.4%) 81 (33.5%) 57 (28.8%)
≥ 3 104 (25.7%) 81 (33.5%) 16 (8.1%)
*

atezolizumab and avelumab datasets: Liver metastasis = liver (+/−other), visceral metastasis = visceral (non-liver, +/− soft tissue/lymph node), soft tissue/lymph node metastasis = soft tissue/lymph node (non-liver, non-visceral); durvalumab dataset: Liver metastasis = liver (+/−other), visceral metastasis = visceral (any non-lymph node metastasis including liver, soft tissue and other visceral metastasis), soft tissue/lymph node metastasis = lymph node metastasis only