Table 2.

Multivariable analysis showing 5 significant factors associated with survival in the derivation atezolizumab dataset

	PI Coefficient	HR	95% CI	p-value
Log NLR	0.661	1.937	1.566–2.395	<0.001
ECOG-PS	0.583	1.792	1.362–2.358	<0.001
Log LDH	0.467	1.596	1.277–1.994	<0.001
Log Platelet count	0.796	2.217	1.544–3.182	<0.001
Liver metastasis	0.437	1.547	1.199–1.997	0.001

C-index of 5-factor model is 0.692 in the derivation dataset; The risk groups are based on PI categorization: PI <7.73681 (low risk), 7.73681≤ PI <8.91837 (moderate risk), PI ≥ 8.91837 (high risk). Legend: NLR=Neutrophils-lymphocyte ratio; ECOG-PS=Eastern Cooperative Oncology Group performance status; LDH=lactate dehydrogenase; HR=hazard ratio; CI=confidence interval