. Author manuscript; available in PMC: 2021 Oct 1.

Published in final edited form as: Disabil Health J. 2020 Jun 10;13(4):100947. doi: 10.1016/j.dhjo.2020.100947

Appendix 1:

Adjusted odds ratios for causes of death by age stratified by Down syndrome status, 2013–2017 US Multiple Cause-of-Death Mortality files (N=13,332,871)

Adults with Down syndrome (N=9,870)			Adults without Down syndrome (N=13,323,001)
	AOR	95% CI	AOR	95% CI
Dementia/Alzheimer’s
Age	1.75^***	(0.92, 0.98)	0.85^***	(0.85, 0.86)
Age²	1.00^***	(0.99, 1.00)	1.00^***	(1.00, 1.00)
Year	1.01	(0.97, 1.04)	0.99^***	(0.99, 1.00)
Intercept	0.00^***	(0.00, 0.00)	0.01^***	(0.01. 0.01)
Heart Disease
Age	0.95^*	(0.92, 0.98)	1.07^***	(1.07, 1.07)
Age²	1.00^*	(1.00, 1.00)	1.00^***	(1.00, 1.00)
Year	0.97	(0.93, 1.01)	0.99^***	(0.99, 0.99)
Intercept	0.76	(0.35, 1.61)	0.02^***	(0.02, 0.02)
InfluenzaPneumonia
Age	0.99	(0.96, 1.03)	0.97^***	(0.97, 0.97)
Age²	1.00	(1.00, 1.00)	1.00^***	(1.00, 1.00)
Year	0.93^*	(0.89, 0.97)	0.97^***	(0.97, 0.97)
Intercept	0.16^***	(0.07, 0.39)	0.02^***	(0.02, 0.02)
Pneumonitis
Age	1.16^***	(1.10, 1.24)	0.95^***	(0.95, 0.96)
Age²	1.00^***	(0.99, 1.00)	1.00^***	(1.00, 1.00)
Year	1.00	(0.95, 1.05)	1.00	(1.00, 1.01)
Intercept	0.00^***	(0.00, 0.01)	0.01^***	(0.00, 0.01)
CVA
Age	0.96	(0.90, 1.02)	1.01^***	(1.01, 1.01)
Age²	1.00	(1.00, 1.00)	1.00^***	(1.00, 1.00)
Year	1.06	(0.98, 1.15)	1.01^***	(1.01, 1.02)
Intercept	0.08^*	(0.02, 0.38)	0.01^***	(0.01, 0.01)
Respiratory Failure
Age	0.96	(0.90, 1.03)	1.06^***	(1.05, 1.07)
Age²	1.00	(1.00, 1.00)	1.00^***	(1.00, 1.00)
Year	1.11^*	(1.02, 1.22)	1.09^***	(1.09, 1.10)
Intercept	0.08^*	(0.02, 0.43)	0.00^***	(0.00, 0.00)
Genitourinary diseases
Age	1.03	(0.95, 1.12)	1.07^***	(1.07, 1.08)
Age²	1.00	(1.00, 1.00)	1.00^***	(1.00, 1.00)
Year	1.04	(0.95, 1.14)	1.00^***	(1.00, 1.00)
Intercept	0.01^***	(0.00, 0.08)	0.00^***	(0.00, 0.00)
Choking
Age	0.96	(0.89, 1.03)	0.99	(0.99, 1.00)
Age²	1.00	(1.00, 1.00)	1.00	(1.00, 1.00)
Year	0.99	(0.90, 1.08)	1.00^***	(0.99, 1.00)
Intercept	0.10^*	(0.02, 0.52)	0.00	(0.00, 0.00)
Congenital Heart Defect
Age	1.05	(0.97, 1.13)	0.96^***	(0.95, 0.97)
Age²	1.00^*	(1.00, 1.00)	1.00^***	(1.00, 1.00)
Year	1.00	(0.90, 1.10)	0.98	(0.97, 1.00)
Intercept	0.09^*	(0.02, 0.39)	0.01^***	(0.01, 0.01)
Malignant Neoplasms
Age	0.96	(0.89, 1.03)	1.37^***	(1.37, 1.38)
Age²	1.00	(1.00, 1.00)	1.00^***	(1.00, 1.00)
Year	1.11^*	(0.90, 1.08)	0.98^***	(0.98, 0.98)
Intercept	0.21^*	(0.05, 0.94)	0.00^***	(0.00, 0.00)
Unknown/Unspecified
Age	1.05^*	(1.00, 1.10)	0.90^***	(0.90, 10.90)
Age²	1.00^*	(1.00, 1.00)	1.00^***	(1.00, 1.00)
Year	0.99	(0.94, 1.04)	0.95^***	(0.95, 0.95)
Intercept	0.03^***	(0.01, 0.10)	0.24^***	(0.22, 0.25)

Note: AOR=adjusted odds ratio;

^***

p<.001;

^**

p<.05;

p<.05