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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2020 May 11;10(2):e382. doi: 10.1002/wdev.382

FIGURE 1.

FIGURE 1

Vesicles involved in retrograde axonal transport and signaling. After ligand binding receptors are typically internalized at the plasma membrane of distal axons. RAB5 or early endosome Antigen1 (EEA1) is a marker for early endosomes where the cargo is sorted into different endocytic compartments, while RAB7 is thought to control the maturation of late endosomes, their retrograde trafficking, and fusion to lysosomes. RAB5 or RAB7 labeled vesicles, lysosomes, and autophagosomes have all been observed to undergo retrograde transport. The intralumenal vesicles (ILVs) accumulate in the lumen of endosomes, which consequently change their composition and morphology to convert into a multivesicular body (MVB), which can also be retrogradely transported