TABLE 1.
Vesicles known to retrogradely transport the cargo in different kinds of neurons
| Organelle (marker) | Cargo | Neuron | References |
|---|---|---|---|
| Autophagosome (LC3) | Cytosolic proteins (S, H), ubiquitin (S, H) | Sensory Hippocampal |
Maday, Wallace, & Holzbaur (2012) Maday et al. (2014) |
| Early endosome (RAB5/EEA1) | NGF (S), p-TRK-A & other TRK signaling proteins(S), TRK-B (M), p75NTR (M), [(P)2X3] (S), TRK-A (Sym), p75NTR (Sym) | Sensory Motor Sympathetic |
Delcroix et al. (2003) Deinhardt et al. (2006) Chen et al. (2012) Barford et al. (2018) Escudero et al. (2019) |
| Late endosomes (RAB7) | P75NTR (M), TRK-B (C), purinergic receptor [(P)2X3] (S), TRK-A(Sym) | Motor Cortical sensory sympathetic |
Deinhardt et al. (2006) Zhou et al. (2012) Chen et al. (2012) Barford et al. (2018) |
| Lysosomes (LAMP1/Cathepsin) | β-Secretase (BACE1), amyloid-β | Cortical | Gowrishankar et al. (2015) |
| Multivesicular bodies (MVB; CD63) | TRK-A (Sym), p75NTR (Sym) | Sympathetic |
Ye et al. (2018) Pathak et al. (2018) |
| Recycling endosomes (RAB11) | TRK-A(Sym) | Sympathetic | Barford et al. (2018) |
Note: Neuron type is indicated in parenthesis next to the cargo. S, sensory; H, hippocampal; M, motor; Sym, sympathetic. Cargoes in bold indicate overexpressed, otherwise endogenous. Cargoes and references in green are for progressive signaling, red is for regressive signaling and black is undetermined.