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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Cancer Treat Rev. 2020 Aug 20;90:102091. doi: 10.1016/j.ctrv.2020.102091

Figure 2. Summary of the functional roles of BAP1.

Figure 2.

BAP1 regulates the DNA damage repair pathway through interactions with BRCA1, BARD1, and RAD51.[8,9,20] BAP1 interacts with host-cell control factor 1 (HCF1) in a number of processes involved in cell-cycle control and cell proliferation.[10,23,24] BAP1 binds to ASXL to form the PR-DUB complex, responsible for regulation of chromatin through Histone H2A deubiquitination.[7] BAP1 is associated in a number of regulated cell death pathways including apoptosis and ferroptosis.[11,25,26] BAP1 is implicated in immune regulation.[12,27,28]