. Author manuscript; available in PMC: 2021 Nov 1.

Published in final edited form as: Cancer Treat Rev. 2020 Aug 20;90:102091. doi: 10.1016/j.ctrv.2020.102091

Table 1.

Tumors Commonly Associated with BAP1 Germline Alterations (BAP1-Tumor Predisposition Syndrome (BAP1-TPDS)).[32]

	Patients with Germline BAP1 Alterations (Total, N=215)		Median Age of Onset (years)
Tumor Type	No. of tumors of specific class, N	% of patients with tumor of specific class	Tumors with Germline BAP1 Mutations	Sporadic Tumors
Uveal melanoma	60	28%	59	62
Malignant mesothelioma	48	22%	46	74
Cutaneous melanoma	38	18%	43	61
Renal cell carcinoma	20	9%	51	64
Basal cell carcinoma	14	7%	41	75
BAP1-inactivated melanocytic tumor (BIMT)^*	40	75%	31	24

Of the total 215 patients with BAP1-TPDS, 53 underwent the necessary total body skin examination to diagnose BIMT; of these, 40 patients (75%) had a positive diagnosis for one or more BIMTs.