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. Author manuscript; available in PMC: 2021 Nov 5.
Published in final edited form as: Cell Stem Cell. 2020 Aug 20;27(5):732–747.e7. doi: 10.1016/j.stem.2020.08.001

Figure 4. Fetal identity gene enhancers remain accessible and primed in adult HSCs and HPCs.

Figure 4.

(A) ATAC-seq (red), H3K4me1 (green) and H3K27ac (purple) peaks for enhancers that map within 100 kB of fetal identity genes. (B-D) Aggregate H3K4me1 and H3K27ac levels in adult HSCs and HPCs. (E) Aggregate ATAC-seq profiles for the same enhancers. (F, G) The gene bodies of Hmga2 and Igf2bp2 have qualitatively higher H3K4me1 in fetal HSCs and HPCs (arrows). (H) Aggregate histograms of H3K27me3 at promoters and enhancers associated with fetal and adult identity genes. (I) HOMER analysis of fetal identity gene promoters.