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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Exp Eye Res. 2020 Sep 14;200:108241. doi: 10.1016/j.exer.2020.108241

Figure 1. Evidence for a second, diurnally expressed, site of action for CB1 in regulation of OP.

Figure 1.

A) CB1 knockouts have lower baseline ocular pressure relative to WT controls. B) CB1 antagonist SR141716 (SR1) raises pressure at mid-day as expected in mice maintained in standard light cycle, but C) lowers IOP in reverse light cycle. D) SR1 has no effect in CB1 knockout males, but does lower IOP in females (E). A,E ***, p<0.001, unpaired t-test. B-C) *, p<0.05, p<0.01, paired t-test.