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A) A single treatment with SR141716 (SR1, 1mM) does not last 24 hours but does result in a rebound at 48 hrs. B) A 7-day daily treatment results in a persistent lowering of IOP (24 hrs after 6th treatment) though there may be some cross-over into vehicle treated eye. C) SR141716 effects do not show evidence of desensitization with repeated 7-day treatments. *, p<0.05, ***, p<0.005 by 1-sample t test vs. 0 (0 = no change).
