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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: J Am Pharm Assoc (2003). 2020 Aug 25;60(6):e236–e245. doi: 10.1016/j.japh.2020.08.002
Medication No. active
users (≥10 d)
Positive predictive value
% (95% CI)
Negative predictive value
% (95% CI)
Sensitivity
% (95% CI)
Specificity
% (95% CI)
Accuracy
% (95% CI)
Aspirin 157 85.8 (80.1–90.1) 91.9 (88.6–94.2) 84.7 (78.1–90.0) 92.5 (88.9–95.2) 89.8 (86.6–92.4)
NSAIDs 18a 14.3 (3.9–40.9) 98.2 (97.9–98.5) 11.1 (1.4–34.7) 98.6 (97.6–99.3) 96.9 (95.5–97.9)
 Ibuprofen 13 15.4 (4.3–42.5) 97.5 (96.9–98.0) 15.4 (1.9–45.5) 97.5 (95.5–98.7) 95.1 (92.7–96.9)
 Naproxen 5 0 98.9 (98.9–98.9) 0 (0–52.2) 99.8 (98.8–100) 98.7 (97.1–99.5)
PPIs 89 67.0 (59.3–73.8) 98.9 (98.2–99.3) 84.3 (75.0–91.1) 97.1 (96.0–97.9) 96.2 (95.1–97.2)
 Omeprazole 76 65.3 (57.4–72.5) 96.6 (94.4–98.0) 84.2 (74.0–91.6) 90.9 (87.5–93.6) 89.8 (86.6–92.4)
 Esomeprazole 8 77.8 (46.1–93.5) 99.8% (98.6–100) 87.5 (47.4–99.7) 99.6 (98.4–100) 99.3 (98.1–99.9)
 Lansoprazole 5 80.0 (35.0–96.8) 99.8 (98.7–100) 80.0 (28.4–99.5) 99.8 (98.8–100) 99.6 (98.4–100)

OTC, over-the-counter; EHR, electronic health record; NSAID, nonsteroidal anti-inflammatory drug; PPI, proton pump inhibitor.

a

Two patients were actively using both ibuprofen and naproxen for 10+ days each.