| Over-the-counter medication |
Prescription medication | |||||
|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers |
Nonsteroidal anti-inflammatory drugs |
Loop diuretics |
P2Y12 platelet antagonists |
Antineoplastic agents |
Direct oral anticoagulants |
|
| Aspirin | 7 | 3 | 7 | 2 | – | – |
| Ibuprofen | 22 | 9 | 4 | 2 | 1 | – |
| Naproxen | – | 4a | 3 | – | – | 1 |
| Omeprazole | – | – | – | 2 | 2b | – |
| Esomeprazole | – | – | – | – | – | – |
| Lansoprazole | – | – | – | 1 | – | – |
| Total (n = 70) | 29 | 16 | 14 | 7 | 3 | 1 |
a
Three of these 4 cases were a class D interaction (naproxen with aspirin). The additional case was a class C interaction (naproxen with ibuprofen).
b
One of these 2 cases was a class D interaction (omeprazole with tacrolimus). The other case was a class C interaction (omeprazole with cyclosporine).