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. Author manuscript; available in PMC: 2021 Nov 6.
Published in final edited form as: Org Lett. 2020 Oct 9;22(21):8307–8312. doi: 10.1021/acs.orglett.0c02938

Table 1.

Cell Viability Data of Synthesized, Simplified Analogs of Ophiobolin A and Natural Congenersa

Cell lines (IC50, μM)╲OpA & derivatives graphic file with name nihms-1641974-t0007.jpg graphic file with name nihms-1641974-t0008.jpg graphic file with name nihms-1641974-t0009.jpg graphic file with name nihms-1641974-t0010.jpg graphic file with name nihms-1641974-t0011.jpg graphic file with name nihms-1641974-t0012.jpg graphic file with name nihms-1641974-t0013.jpg
MCF10A 197 ± 14.4b 13.4 ± 3.10 6.36 ± 1.99 0.198 ± 0.076 1.05 ± 0.076 1.74 ± 0.614 4.16 ± 0.763
MDA-MB-231 44.2 ± 16.1b 11.0 ± 0.935 7.09 ± 2.20 0.069 ± 0.024 0.80 ± 0.28 0.552 ± 0.124 4.94 ± 0.921
a

IC50 values are denoted in mean ± standard deviation of at least 3 independent replicates.

b

Ketoaldehyde (± )-11 was unstable in DMSO and thus a freshly prepared sample was required to preclude inconsistencies observed when using stored DMSO stock solutions.