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. 2020 Nov 10;10:19462. doi: 10.1038/s41598-020-76291-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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OvC-PDE cultures are amenable for ex vivo evaluation of chemotherapy efficacy. (A) Resazurin reduction capacity (% relative to control) of OvC-PDE cultures at day 0, 7 and 14 of drug challenge (DC, corresponding to day 7, 14 and 21 of culture) with 25 µg/mL carboplatin and 10 µg/mL paclitaxel. Two-way ANOVA statistical test (Tukey’s multiple comparison test) was applied to compare the mean values of resazurin reduction of OvC-PDE culture after each drug challenge versus control culture. Statistical analysis was carried out using GraphPad Prism 6 Software. *(p < 0.05) and **(p < 0.01); (B) proliferation (Ki67⁺ cells) and (C) apoptosis (cleaved caspase 3+ cells) quantification in cross-sections of OvC-PDE cultures challenged with chemotherapy agents. Data in (A–C) are presented as a mean ± SD (N = 4, OVC15, OVC16, OVC23 and OVC24).