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. 2020 Oct 28;10:570733. doi: 10.3389/fonc.2020.570733

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Copyright © 2020 Guo, Ma, He, Jiang, Xia, Pan, Wei, Shi, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of DE-miRNAs. (A) Heatmap of DE-miRNAs. The black patterns represent miRNAs that are not differentially expressed between 483 human LUAD tumor samples and 45 human normal samples. The red patterns represent up-regulated miRNAs and the green represent down-regulated miRNAs. (B) Volcano plot of DE-miRNAs. The black plots represent miRNAs with no difference, while the red plots represent up-regulated miRNAs and the green plots represent down-regulated miRNAs. (C–E) The expression of miR-550a-1, miR-550a-2, and miR-4661 in tumor tissues was compared with that in normal tissues in LUAD patients from TCGA database. (F,G) Survival curve of hsa-miR-550a and hsa-miR-4661 in LUAD from the Kaplan–Meier database.